Patched (Ptc) is a conserved 12-pass transmembrane protein receptor that plays an obligate negative regulatory role in the Hedgehog signaling pathway in insects and vertebrates. Patched is an essential gene in embryogenesis for proper segmentation in the fly embryo, mutations in which may be embryonic lethal. Patched functions as the receptor for the Hedgehog protein and controls its spatial distribution, in part via endocytosis of bound Hedgehog protein, which is then targeted for lysosomal degradation.
Unfabulous
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Not fabulous.
Its a show on Nick about a girl that whines
Unfabulous meaning & definition 1 of Unfabulous.
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THE WORST SHOW ON EARTH. wow seriously if u like this show= u have NO LIFE
Unfabulous meaning & definition 2 of Unfabulous.
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A show about a girl that cant sing worth a damn and knows her life sucks so she makes everyone elses life suck by singing songs about her awful life.
Unfabulous meaning & definition 3 of Unfabulous.
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a stupid show on disney channel, that a girl cant freakin sing on.
Unfabulous meaning & definition 4 of Unfabulous.
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