Patched (Ptc) is a conserved 12-pass transmembrane protein receptor that plays an obligate negative regulatory role in the Hedgehog signaling pathway in insects and vertebrates. Patched is an essential gene in embryogenesis for proper segmentation in the fly embryo, mutations in which may be embryonic lethal. Patched functions as the receptor for the Hedgehog protein and controls its spatial distribution, in part via endocytosis of bound Hedgehog protein, which is then targeted for lysosomal degradation.
Clodhopper
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Big, oversized boots or shoes that make clunky noises on the floor when you are walking.
Clodhopper meaning & definition 1 of Clodhopper.
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An extremely clumsey and awkward person.
Clodhopper meaning & definition 2 of Clodhopper.
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large ungainly foot wear weilded in a heavy, uncoordinated fashion.
Clodhopper meaning & definition 3 of Clodhopper.
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being a huge idiot in front of others for no apperent reason
Clodhopper meaning & definition 4 of Clodhopper.
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Addictive shit.
Clodhopper meaning & definition 5 of Clodhopper.
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A large, heavy shoe.
Clodhopper meaning & definition 6 of Clodhopper.
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a person who moves in an awkward way:
Clodhopper meaning & definition 7 of Clodhopper.
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