Patched (Ptc) is a conserved 12-pass transmembrane protein receptor that plays an obligate negative regulatory role in the Hedgehog signaling pathway in insects and vertebrates. Patched is an essential gene in embryogenesis for proper segmentation in the fly embryo, mutations in which may be embryonic lethal. Patched functions as the receptor for the Hedgehog protein and controls its spatial distribution, in part via endocytosis of bound Hedgehog protein, which is then targeted for lysosomal degradation.
Squelcher
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One who does not live up to a commitment.
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A person who breaks the terms of an agreement or contract
Squelcher meaning & definition 1 of Squelcher.
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One who walks along the beach sucking the farts out of dead seagulls
Squelcher meaning & definition 2 of Squelcher.
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A fart that leaves your bumcheeks feeling moist.
Squelcher meaning & definition 3 of Squelcher.
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another name for punk or schoundrel;commonly used by bullies.
Squelcher meaning & definition 4 of Squelcher.
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