Patched (Ptc) is a conserved 12-pass transmembrane protein receptor that plays an obligate negative regulatory role in the Hedgehog signaling pathway in insects and vertebrates. Patched is an essential gene in embryogenesis for proper segmentation in the fly embryo, mutations in which may be embryonic lethal. Patched functions as the receptor for the Hedgehog protein and controls its spatial distribution, in part via endocytosis of bound Hedgehog protein, which is then targeted for lysosomal degradation.
Fogey
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Fogey/fogy /fougi/ sl. (early 18C , orig. Scot) old-fashioned, stuck-in-the mud.
Person with old fashioned ideas which he is unwilling to change: Come to the disco and stop being such an old [fogey]!
Fogey meaning & definition 1 of Fogey.
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Also old fogey, one who is old before their time. Best viewed through their demeanour or their habits.
Fogey meaning & definition 2 of Fogey.
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An elderly person, Usually of the creepy male stature.
Fogey meaning & definition 3 of Fogey.
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A derogatory word for a brown skinned person assumed to be of African decent.
Fogey meaning & definition 4 of Fogey.
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the coolest slacker that i know...
Fogey meaning & definition 5 of Fogey.
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A very old-fashioned or conservative person.
Fogey meaning & definition 6 of Fogey.
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a person who is old-fashioned and likes traditional ways of doing things:
Fogey meaning & definition 7 of Fogey.
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