Patched (Ptc) is a conserved 12-pass transmembrane protein receptor that plays an obligate negative regulatory role in the Hedgehog signaling pathway in insects and vertebrates. Patched is an essential gene in embryogenesis for proper segmentation in the fly embryo, mutations in which may be embryonic lethal. Patched functions as the receptor for the Hedgehog protein and controls its spatial distribution, in part via endocytosis of bound Hedgehog protein, which is then targeted for lysosomal degradation.
Shad
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A person that gets requested by many women to go out on a date. Overall, just a brave person in life.
Shad meaning & definition 1 of Shad.
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The uppermost area of skin on the thigh, just before the vulva.
Shad meaning & definition 2 of Shad.
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shad is a synonym for sexy,
or extremely good looking, its usually
referring to a really hot guy.Shad meaning & definition 3 of Shad.
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A name to call lazy unemployed people who live off the state, and use food stamps on the 1st and 15th of the month, also known to vote for hillary clinton
Shad meaning & definition 4 of Shad.
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Slang word for the shadow which some large-breasted girls have beneath their breasts when they stand directly under a luminous object.
Shad meaning & definition 5 of Shad.
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Awesome..
Shad meaning & definition 6 of Shad.
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Nickname for an awesome guy whose name starts with shad.
Shad meaning & definition 7 of Shad.
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A herring-like fish that spends much of its life in the sea, typically entering rivers to spawn. It is an important food fish in many regions.
Shad meaning & definition 8 of Shad.
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Very tall, powerful presence he makes everyone around him feel safe and warm , a gentle giant , will always defend and protect those he loves, women fantasize about him
Shad meaning & definition 9 of Shad.