Patched (Ptc) is a conserved 12-pass transmembrane protein receptor that plays an obligate negative regulatory role in the Hedgehog signaling pathway in insects and vertebrates. Patched is an essential gene in embryogenesis for proper segmentation in the fly embryo, mutations in which may be embryonic lethal. Patched functions as the receptor for the Hedgehog protein and controls its spatial distribution, in part via endocytosis of bound Hedgehog protein, which is then targeted for lysosomal degradation.
Harass
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- to irritate or torment someone.
not said as her ass
her ass is what you put a skirt on.
Harass meaning & definition 1 of Harass.
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In RTS games such as Warcraft3, it is to continuuously do hit and run attacks until the enemy begins to speak in a colourful language. However this can only be done if you have the upper hand, or when you know the army is away from base.
Harass meaning & definition 2 of Harass.
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rednecks version of her ass
Harass meaning & definition 3 of Harass.
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Gay slang term for a sexual act that involves the knuckles but does not include the entire fist.
Harass meaning & definition 4 of Harass.
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Subject to aggressive pressure or intimidation.
Harass meaning & definition 5 of Harass.
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