Patched (Ptc) is a conserved 12-pass transmembrane protein receptor that plays an obligate negative regulatory role in the Hedgehog signaling pathway in insects and vertebrates. Patched is an essential gene in embryogenesis for proper segmentation in the fly embryo, mutations in which may be embryonic lethal. Patched functions as the receptor for the Hedgehog protein and controls its spatial distribution, in part via endocytosis of bound Hedgehog protein, which is then targeted for lysosomal degradation.
Sniggler
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A sniggler is someone who takes the parking spot you wanted, or who otherwise does something perfectly legitimate, but which nonetheless inconveniences or annoys you.
Sniggler meaning & definition 1 of Sniggler.
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A person with good taste that finds the best, hottest people to have smokin hot intercourse with.
Sniggler meaning & definition 2 of Sniggler.
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- Asshole that steals food from his friend and eats it while they are in the bathroom.
- All around douchebag.
Sniggler meaning & definition 3 of Sniggler.
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