Patched (Ptc) is a conserved 12-pass transmembrane protein receptor that plays an obligate negative regulatory role in the Hedgehog signaling pathway in insects and vertebrates. Patched is an essential gene in embryogenesis for proper segmentation in the fly embryo, mutations in which may be embryonic lethal. Patched functions as the receptor for the Hedgehog protein and controls its spatial distribution, in part via endocytosis of bound Hedgehog protein, which is then targeted for lysosomal degradation.
Aggregate
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A group of items all combining to a sum total.
Aggregate meaning & definition 1 of Aggregate.
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A whole formed by combining several separate elements.
Aggregate meaning & definition 2 of Aggregate.
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The total score of a player or team in a fixture comprising more than one game or round.
Aggregate meaning & definition 3 of Aggregate.
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A material or structure formed from a mass of fragments or particles loosely compacted together.
Aggregate meaning & definition 4 of Aggregate.
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Pieces of broken or crushed stone or gravel used to make concrete and in building.
Aggregate meaning & definition 5 of Aggregate.
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Formed or calculated by the combination of several separate elements; total.
Aggregate meaning & definition 6 of Aggregate.
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(of a group of species) comprising several very similar species formerly regarded as a single species.
Aggregate meaning & definition 7 of Aggregate.
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Denoting the total supply or demand for goods and services in an economy at a particular time.
Aggregate meaning & definition 8 of Aggregate.
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Form or group into a class or cluster.
Aggregate meaning & definition 9 of Aggregate.
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Collect (related items of content) so as to display or link to them.
Aggregate meaning & definition 10 of Aggregate.
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In total; as a whole.
Aggregate meaning & definition 11 of Aggregate.
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in (the) aggregate
Aggregate meaning & definition 12 of Aggregate.