Patched (Ptc) is a conserved 12-pass transmembrane protein receptor that plays an obligate negative regulatory role in the Hedgehog signaling pathway in insects and vertebrates. Patched is an essential gene in embryogenesis for proper segmentation in the fly embryo, mutations in which may be embryonic lethal. Patched functions as the receptor for the Hedgehog protein and controls its spatial distribution, in part via endocytosis of bound Hedgehog protein, which is then targeted for lysosomal degradation.
Populist
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A term for a person or movement that embodies [populism] i.e. anti-intellectualism masquerading as disdain for the elites i.e. anybody who uses facts in an argument. This is generally found in the far-right (or [alt-right], as they like to call themselves now), but far-left populists are not uncommon, just less prone to xenophobic bullshit
Populist meaning & definition 1 of Populist.
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An adjective used by snobby intellectuals and elitists basically as code for this is what morons like.
Populist meaning & definition 2 of Populist.
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A person, especially a politician, who strives to appeal to ordinary people who feel that their concerns are disregarded by established elite groups.
Populist meaning & definition 3 of Populist.
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trying to be popular with ordinary people and to represent their ideas and opinions:
Populist meaning & definition 4 of Populist.
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