Patched (Ptc) is a conserved 12-pass transmembrane protein receptor that plays an obligate negative regulatory role in the Hedgehog signaling pathway in insects and vertebrates. Patched is an essential gene in embryogenesis for proper segmentation in the fly embryo, mutations in which may be embryonic lethal. Patched functions as the receptor for the Hedgehog protein and controls its spatial distribution, in part via endocytosis of bound Hedgehog protein, which is then targeted for lysosomal degradation.
Num Lock
-
Num Lock is a key that is typically located near the keypad on the right side of a keyboard. Like Caps Lock, Num Lock is a toggle key, which toggles the input of certain keys, depending whether Num Lock is on or off.
Num Lock is short for Number Lock. It was implemented in early Windows keyboards to lock the input of the numeric keypad. When Num Lock is on, the keypad only enters numbers. When Num Lock is off, the keys may provide different input as indicated below:
While you may not need to use the Num Lock key with your keyboard, it is helpful to know the keys function. If you find yourself trying to enter numbers with the numeric keypad and nothing appears on the screen, it is possible that Num Lock is OFF. If this is the case, pressing the Num Lock key should fix the problem.
Num Lock meaning & definition 1 of Num Lock.