Patched (Ptc) is a conserved 12-pass transmembrane protein receptor that plays an obligate negative regulatory role in the Hedgehog signaling pathway in insects and vertebrates. Patched is an essential gene in embryogenesis for proper segmentation in the fly embryo, mutations in which may be embryonic lethal. Patched functions as the receptor for the Hedgehog protein and controls its spatial distribution, in part via endocytosis of bound Hedgehog protein, which is then targeted for lysosomal degradation.
Post office
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Term describing a room, bar, club etc:, that has all men in it.
A room full of men.
Post office meaning & definition 1 of Post office.
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n. A public building that deals with a communitys mail. Oh wow, go figure.
Post office meaning & definition 2 of Post office.
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a room filled with all men, (all male).
also see sausage factory.
Post office meaning & definition 3 of Post office.
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The act of putting a [package] with a [box] (i.e. sex)
Post office meaning & definition 4 of Post office.
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a place where stamps are sold and from where letters and parcels are sent
Post office meaning & definition 5 of Post office.
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