Patched (Ptc) is a conserved 12-pass transmembrane protein receptor that plays an obligate negative regulatory role in the Hedgehog signaling pathway in insects and vertebrates. Patched is an essential gene in embryogenesis for proper segmentation in the fly embryo, mutations in which may be embryonic lethal. Patched functions as the receptor for the Hedgehog protein and controls its spatial distribution, in part via endocytosis of bound Hedgehog protein, which is then targeted for lysosomal degradation.
Palmist
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One who specializes in hand jobs.
Palmist meaning & definition 1 of Palmist.
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a person who looks at the lines on the palm of your hand and tells you what these lines say about your character and your future
Palmist meaning & definition 2 of Palmist.
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