Patched (Ptc) is a conserved 12-pass transmembrane protein receptor that plays an obligate negative regulatory role in the Hedgehog signaling pathway in insects and vertebrates. Patched is an essential gene in embryogenesis for proper segmentation in the fly embryo, mutations in which may be embryonic lethal. Patched functions as the receptor for the Hedgehog protein and controls its spatial distribution, in part via endocytosis of bound Hedgehog protein, which is then targeted for lysosomal degradation.
Cissy
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A derogatory term for non-trans people. Often used to express frustration with the oppression faced by transfolk.
Cissy meaning & definition 1 of Cissy.
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An asian teen girl that is a white girl at heart, with a perfect smile , beautiful curley hair and sucks at driving at the moment but will get better in time.
Cissy meaning & definition 2 of Cissy.
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A [cis] gendered person easily [offended] by people being happy discovering who they are and diminishing [gender roles]
Cissy meaning & definition 3 of Cissy.
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A beautiful girl who has a [great personality], kind heart, amazing friend an even better girlfriend. This girl is also crazy but shy [in public] and when she gets horny she gets really [freaky] and you will love everything she tells you.
Cissy meaning & definition 4 of Cissy.
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→ sissy informal disapproving
Cissy meaning & definition 5 of Cissy.
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