Patched (Ptc) is a conserved 12-pass transmembrane protein receptor that plays an obligate negative regulatory role in the Hedgehog signaling pathway in insects and vertebrates. Patched is an essential gene in embryogenesis for proper segmentation in the fly embryo, mutations in which may be embryonic lethal. Patched functions as the receptor for the Hedgehog protein and controls its spatial distribution, in part via endocytosis of bound Hedgehog protein, which is then targeted for lysosomal degradation.
Barger
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Verb. To screw up the installation of flooring in such a way as to make it unwalkable.
Barger meaning & definition 1 of Barger.
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A large breasted woman who growls at you like a wild animal during rough sex.
Barger meaning & definition 2 of Barger.
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The act of skipping a friends planned event without any forewarning, remorse or sense of obligation.
Barger meaning & definition 3 of Barger.
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