Patched (Ptc) is a conserved 12-pass transmembrane protein receptor that plays an obligate negative regulatory role in the Hedgehog signaling pathway in insects and vertebrates. Patched is an essential gene in embryogenesis for proper segmentation in the fly embryo, mutations in which may be embryonic lethal. Patched functions as the receptor for the Hedgehog protein and controls its spatial distribution, in part via endocytosis of bound Hedgehog protein, which is then targeted for lysosomal degradation.
Fold
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To become folded, plaited, or doubled; to close over another ofthe same kind; to double together; as, the leaves of the door fold. 1Kings vi. 34.
Fold meaning & definition 1 of Fold.
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to back down from any thing
Fold meaning & definition 2 of Fold.
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A verb meaning that someone sucks horribly, and fails at almost everything. Origins; Chaminade College, Tronto.
Fold meaning & definition 3 of Fold.
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- To Bitch Out
2.The act of accepting you are a Bitch.
Fold meaning & definition 4 of Fold.
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To Get Played, Switched, Or Turned Down.
Fold meaning & definition 5 of Fold.
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Someone who is fucking old.
Fold meaning & definition 6 of Fold.
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a homemade envelope made from a piece of paper...used to hold Cocaine.
Fold meaning & definition 7 of Fold.
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A classy word for a roll up.
Fold meaning & definition 8 of Fold.
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pussy, vagina, bushy choot, cunt, giney, fanny, muff, poon, cooch, pit, vice grip.........
Fold meaning & definition 9 of Fold.
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To Knock some one out were they fold like a piece of paer
Fold meaning & definition 10 of Fold.
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To have sexual intercourse with a female. It derives from the act of origami in which one folds creases. However, rather than a crease in folding paper, you fold someone over a bed and caress the creases of their sides while stroking.
Fold meaning & definition 11 of Fold.
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In an amount multiplied by.
Fold meaning & definition 12 of Fold.