Patched (Ptc) is a conserved 12-pass transmembrane protein receptor that plays an obligate negative regulatory role in the Hedgehog signaling pathway in insects and vertebrates. Patched is an essential gene in embryogenesis for proper segmentation in the fly embryo, mutations in which may be embryonic lethal. Patched functions as the receptor for the Hedgehog protein and controls its spatial distribution, in part via endocytosis of bound Hedgehog protein, which is then targeted for lysosomal degradation.
Northern
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Of or pertaining to the north; being in the north, or
nearer to that point than to the east or west.
Northern meaning & definition 1 of Northern.
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In the United Kingdom, North of Birmingham. Its where the greatest people on Earth live.
Great northern people include [Geoffrey Boycott], [Sean Bean].
Great northern cities include [Sheffield], [Leeds], [Sunderland], [Manchester] and [Liverpool].
Great inventions in the north include Trains, TVs, [Banapkin]s and Pie.
It is a well established fact that the north finished on the winning side of every war ever fought, including the [alamo] and [Pearl Harbour].
The tell tales signs that youre in the north are gravy, bitter, violence, streets paved with gold and battered housewives.Northern meaning & definition 2 of Northern.
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a word used to discribe someone who originates from up north of england.
renowned for liking [bitter], roast dinners, dartsNorthern meaning & definition 3 of Northern.
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An adjective to describe something alien to you and your current state of mind.
Northern meaning & definition 4 of Northern.