Patched (Ptc) is a conserved 12-pass transmembrane protein receptor that plays an obligate negative regulatory role in the Hedgehog signaling pathway in insects and vertebrates. Patched is an essential gene in embryogenesis for proper segmentation in the fly embryo, mutations in which may be embryonic lethal. Patched functions as the receptor for the Hedgehog protein and controls its spatial distribution, in part via endocytosis of bound Hedgehog protein, which is then targeted for lysosomal degradation.
Monument
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Something which stands, or remains, to keep in
remembrance what is past; a memorial.
Monument meaning & definition 1 of Monument.
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Monument is a small truck-stop town in Colorado located roughly in between [Colorado Springs] and [Castle Rock]. To the citizens of Monument, this place is known for the excess of preps, white trash, a huge pop-punk music scene, and [bitchy people] complaining about how they dont like some aspect of this town(like me). If you ever visit Monument, tourist attractions are:
-Getting drunk
-Getting high
-Having sex
-Getting drunk, high, and having sex on Mt. Herman.Monument meaning & definition 2 of Monument.
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A town full of [privileged] kids and lacks [hardly] any [diversity].
Monument meaning & definition 3 of Monument.
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A street in [Concord], California with [a heavy] [Hispanic] population
Monument meaning & definition 4 of Monument.
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A statue, building, or other structure erected to commemorate a notable person or event.
Monument meaning & definition 5 of Monument.
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a jealous dried female, out of her [witness] for a non- [tiring] [love affair] of a couple of lovers.
Monument meaning & definition 6 of Monument.
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AutoML toolkit that runs anywhere. It specializes in time series data, and can run high-performance algos without GPUs. A software product by MonumentAI
Monument meaning & definition 7 of Monument.