Patched (Ptc) is a conserved 12-pass transmembrane protein receptor that plays an obligate negative regulatory role in the Hedgehog signaling pathway in insects and vertebrates. Patched is an essential gene in embryogenesis for proper segmentation in the fly embryo, mutations in which may be embryonic lethal. Patched functions as the receptor for the Hedgehog protein and controls its spatial distribution, in part via endocytosis of bound Hedgehog protein, which is then targeted for lysosomal degradation.
Gangbusters
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Gang Busters was a famous radio program that was first heard in 1936 and aired until 1957. The sound effects of police sirens, tommyguns, and screeching tires that opened the show were dramatic and exciting -- this inspired the expression coming on like gangbusters.
Usage has opened up to describe things that are not just exciting, but successful, intense, and many other adjectives, and many drop the coming on like prefix. I think we should be more careful about how we use it, and keep it true to its origin -- something that starts with much excitement and drama is coming on like gangbusters.
Gangbusters meaning & definition 1 of Gangbusters.
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Also used in conjunction with like, to create like gangbusters. This phrase can be used to describe something energetic or intense.
Gangbusters meaning & definition 2 of Gangbusters.
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most commonly used in conjunction with like to describe something that is extremely effective
Gangbusters meaning & definition 3 of Gangbusters.
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used to describe an action displaying a complete lack of subtlety
Gangbusters meaning & definition 4 of Gangbusters.
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A bad ass collaboration of two bad ass Djs from seattle.
JAMEGangbusters meaning & definition 5 of Gangbusters.
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to show a large amount of energy, activity, speed, or success:
Gangbusters meaning & definition 6 of Gangbusters.