Patched (Ptc) is a conserved 12-pass transmembrane protein receptor that plays an obligate negative regulatory role in the Hedgehog signaling pathway in insects and vertebrates. Patched is an essential gene in embryogenesis for proper segmentation in the fly embryo, mutations in which may be embryonic lethal. Patched functions as the receptor for the Hedgehog protein and controls its spatial distribution, in part via endocytosis of bound Hedgehog protein, which is then targeted for lysosomal degradation.
Rando
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a random person or thing
Rando meaning & definition 1 of Rando.
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That which is random. Generally used in reference to people.
Rando meaning & definition 2 of Rando.
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an unpredictable, awkward and often creepy individual. a rando is always there in the background, even though no one invited him. Randos tend to be isolated within large groups; they sit in corners and lurk in the shadows of others. Even though everyone is aware of the presence of a rando, no one knows anything about him or her and therefore randos are often unwittingly ignored.
Rando meaning & definition 3 of Rando.
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a shorter word for random. Used mainly to describe something excessively random like situations on family guy or situations in life that are outta left field
Rando meaning & definition 4 of Rando.
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Is the nickname of Randy. Usually means he is to cool to be called by his real name.
Rando meaning & definition 5 of Rando.
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A way of describing someone of sound character and mind with strong leadership and calming, cool and collective demeanor. Persons of high intellectual mindset and logical thinkers bear this description.
Rando meaning & definition 6 of Rando.
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Totally unexpected. To be surprising.
Rando meaning & definition 7 of Rando.
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Usually used to describe members of the female sex who are hammered and/or of questionable cleanliness and morality....we do not know their names, we do not want to know their names. For some, they are to be avoided. For others, they are sought after while in an inebriated state. For still others, they are sought after, then upon waking in the morning, immediately regretted.
Rando meaning & definition 8 of Rando.
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A person one does not know, especially one regarded as odd, suspicious, or engaging in socially inappropriate behavior.
Rando meaning & definition 9 of Rando.